MovDisordV3, Main, Exploration, bibRecord, 004C75

Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's disease

Identifieur interne : 004C75 ( Main/Exploration ); précédent : 004C74; suivant : 004C76

Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's disease

Auteurs : Bruno Barbiroli ; Paolo Martinelli [Italie] ; Alberto Patuelli ; Raffaele Lodi ; Stefano Iotti ; Pietro Cortelli [Italie] ; Pasquale Montagna [Italie]

Source :

Movement Disorders [ 0885-3185 ] ; 1999-05.

RBID : ISTEX:3D7B405F828F9E2291854971AE9034DCBF720AFB

Descripteurs français

Pascal (Inist)
- Adulte, Atrophie multisystématisée, Diagnostic différentiel, Etude comparative, Exploration, Forme clinique, Intracellulaire, Magnésium ion, Métabolisme, Parkinson maladie, Phosphate, Phosphore, Spectrométrie RMN, pH.
Wicri :
- topic : Adulte, Magnésium, Phosphate, Phosphore.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Brain, Brain (metabolism), Clinical form, Comparative study, Cytosol (metabolism), Differential diagnostic, Exploration, Female, Humans, Hydrogen-Ion Concentration, Intracellular, Magnesium, Magnesium (metabolism), Magnesium ion, Magnetic Resonance Spectroscopy (diagnostic use), Male, Metabolism, Middle Aged, Multiple System Atrophy (complications), Multiple System Atrophy (metabolism), Multiple system atrophy, NMR spectrometry, Occipital Lobe (metabolism), Parkinson Disease (complications), Parkinson Disease (metabolism), Parkinson disease, Parkinson's disease, Phosphates, Phosphates (metabolism), Phosphocreatine, Phosphocreatine (metabolism), Phosphorus, Phosphorus (metabolism), Phosphorus magnetic resonance spectroscopy, Severity of Illness Index, pH.
MESH :
- chemical , metabolism : Magnesium, Phosphates, Phosphocreatine, Phosphorus.
- complications : Multiple System Atrophy, Parkinson Disease.
- diagnostic use : Magnetic Resonance Spectroscopy.
- metabolism : Brain, Cytosol, Multiple System Atrophy, Occipital Lobe, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Female, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Severity of Illness Index.

Abstract

We performed in vivo phosphorus magnetic resonance spectroscopy on the occipital lobes of 15 patients with multiple system atrophy (MSA; eight with olivopontocerebellar atrophy [OPCA] and seven with the striatonigral degeneration variant [SND]), 13 patients with idiopathic Parkinson's disease (PD), and 16 age‐matched healthy subjects. The MSA group showed significantly reduced phosphocreatine (PCr), increased inorganic phosphate (Pi), and unchanged cytosolic free [Mg2+], and pH. We did not find any significant difference between the OPCA and SND variants. However, patients with PD showed significantly increased content of Pi, decreased cytosolic free [Mg2+], and unchanged [PCr] and pH. Comparing the MSA and PD groups, [PCr] was significantly lower in MSA than in PD, whereas cytosolic free [Mg2+] was significantly lower in PD. Despite a certain degree of overlap of [PCr] and [Mg2+] values between the two groups, by considering both variables at the same time it was possible to classify correctly 93% of cases by discriminant analysis. We conclude that phosphorus magnetic resonance spectroscopy discloses abnormal phosphate metabolite and ion contents in both MSA and PD, respectively, and may provide noninvasive diagnostic help to differentiate MSA from PD.

Url:

https://api.istex.fr/document/3D7B405F828F9E2291854971AE9034DCBF720AFB/fulltext/pdf

DOI: 10.1002/1531-8257(199905)14:3<430::AID-MDS1007>3.0.CO;2-S

Affiliations:

Le document en format XML

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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Brain</term>
<term>Brain (metabolism)</term>
<term>Clinical form</term>
<term>Comparative study</term>
<term>Cytosol (metabolism)</term>
<term>Differential diagnostic</term>
<term>Exploration</term>
<term>Female</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
<term>Intracellular</term>
<term>Magnesium</term>
<term>Magnesium (metabolism)</term>
<term>Magnesium ion</term>
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<term>Male</term>
<term>Metabolism</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (complications)</term>
<term>Multiple System Atrophy (metabolism)</term>
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<term>Occipital Lobe (metabolism)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
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<term>Phosphocreatine (metabolism)</term>
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<term>Phosphorus (metabolism)</term>
<term>Phosphorus magnetic resonance spectroscopy</term>
<term>Severity of Illness Index</term>
<term>pH</term>
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<term>Phosphates</term>
<term>Phosphocreatine</term>
<term>Phosphorus</term>
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<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="diagnostic use" xml:lang="en"><term>Magnetic Resonance Spectroscopy</term>
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<term>Cytosol</term>
<term>Multiple System Atrophy</term>
<term>Occipital Lobe</term>
<term>Parkinson Disease</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Hydrogen-Ion Concentration</term>
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<term>Middle Aged</term>
<term>Severity of Illness Index</term>
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<term>Atrophie multisystématisée</term>
<term>Diagnostic différentiel</term>
<term>Etude comparative</term>
<term>Exploration</term>
<term>Forme clinique</term>
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<term>Phosphate</term>
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<front><div type="abstract" xml:lang="en">We performed in vivo phosphorus magnetic resonance spectroscopy on the occipital lobes of 15 patients with multiple system atrophy (MSA; eight with olivopontocerebellar atrophy [OPCA] and seven with the striatonigral degeneration variant [SND]), 13 patients with idiopathic Parkinson's disease (PD), and 16 age‐matched healthy subjects. The MSA group showed significantly reduced phosphocreatine (PCr), increased inorganic phosphate (Pi), and unchanged cytosolic free [Mg2+], and pH. We did not find any significant difference between the OPCA and SND variants. However, patients with PD showed significantly increased content of Pi, decreased cytosolic free [Mg2+], and unchanged [PCr] and pH. Comparing the MSA and PD groups, [PCr] was significantly lower in MSA than in PD, whereas cytosolic free [Mg2+] was significantly lower in PD. Despite a certain degree of overlap of [PCr] and [Mg2+] values between the two groups, by considering both variables at the same time it was possible to classify correctly 93% of cases by discriminant analysis. We conclude that phosphorus magnetic resonance spectroscopy discloses abnormal phosphate metabolite and ion contents in both MSA and PD, respectively, and may provide noninvasive diagnostic help to differentiate MSA from PD.</div>
</front>
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<name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name>
<name sortKey="Patuelli, Alberto" sort="Patuelli, Alberto" uniqKey="Patuelli A" first="Alberto" last="Patuelli">Alberto Patuelli</name>
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Movement Disorders (revue)

Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's disease

Phosphorus magnetic resonance spectroscopy in multiple system atrophy and Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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